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KMID : 0387420040150020053
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Korean Society of Oriental Neuropsychiatry
2004 Volume.15 No. 2 p.53 ~ p.70
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The effects of Bambusae Caulis and St. John’s Wort in the chronic mild stress model of depression in rats
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Park Se-Jin
Kim Jong-Woo
Kim Hyun-Taek
Chi Sang-Eun
Kim Woon-Ryoung
Hwang Wei-Wan
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Abstract
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Objective:This study was designed to assess the protective effects of Bambusae caulis and St. John’s Wort on the animal model of depression, induced by chronic mild stress(CMS)
Method: Male Wistar rats were used for this experiment. The subjects were divided into 4 groups ( 1. CMS-drugs: Bambusae caulis administered during CMS treatment, 2. CMS-drugs: St. John’s Wort administered during CMS treatment, 3. CMS-vehicle: Water administered during CMS treatment, 4. normal control group without CMS treatment ). After 3 weeks of CMS treatment, they were executed open field test and weight, sucrose intake were measured.
Results:1. CMS Bambusae caulis group showed significant difference of locomotor activities and marginal difference of start latency in comparison with other groups in open field test. 2. There was no change of weights between CMS Bambusae caulis, St. John’s Wort groups and CMS control group. 3. CMS St. John’s Wort group showed upper level of sucrose intake than CMS Bambusae caulis group and CMS control group.
Conclusion: These results suggest that Bambusae caulis may have protective antidepressant effects in CMS model rats. And these effects could be explained by the elevated locomotor activities in open field test.
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KEYWORD
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Bambusae caulis, St. John’s Wort, Chronic mild stress, Open field test
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